Gynaecological infections, Intra-abdominal infections, Prophylaxis of surgical infections, Respiratory tract infections
Oral Gynaecological infections, Intra-abdominal infections, Prophylaxis of surgical infections, Respiratory tract infections Adult: As tablet containing ciprofloxacin (mg)/tinidazole (mg): 500/600, 250/300. Usually 1 tablet bid for 5-10 days depending on severity and response.
Adverse drug reactions
Nausea, headache, vomiting, fatigue, abdominal pain, depression, dyspepsia, constipation, dry mouth, sometimes diarrhea, metallic taste, urticaria, erythema & rashes; rarely convulsions & hematological changes. Potentially Fatal: Severe hypersensitivity reaction (rarely).
Antacids, sucralfate, calcium, Fe & Zn prep reduce absorption of ciprofloxacin. Concurrent use with ciclosporin may lead to transient increases in serum creatinine levels. Increases plasma levels and elimination half-life of theophylline; potentiates oral anticoagulant effects; disulfiram-like effect with alcohol. May affect metabolism of caffeine resulting in reduced clearance of caffeine.
Mech of action
Ciprofloxacin is bactericidal against enteropathogens like Shigella, Salmonella, E coli, C jejuni, Vibrio cholerae etc.It acts by inhibition of DNA synthesis. Tinidazole is a potent anaerobicide. It is also effective against Entameba & Giardia. It acts by damaging DNA strands. This combination has the advantage of being effective against both bacteria & protozoa. Entameba requires normal faecal flora for its survival; ciprofloxacin kills the pathogenic intestinal bacteria & alters intestinal flora, & tinidazole directly eradicates Entameba. This combination can also be used in other systemic infections caused by susceptible organisms.
J01MA02 - ciprofloxacin; Belongs to the class of quinolones, fluoroquinolone. Used in the treatment of systemic infections. J01XD02 - tinidazole; Belongs to the class of imidazole derivative antibacterials. Used in the treatment of systemic infections. P01AB02 - tinidazole; Belongs to the class of nitroimidazole derivatives antiprotozoals. Used in the treatment amoebiasis and other protozoal diseases. S01AX13 - ciprofloxacin; Belongs to the class of other antiinfectives. Used in the treatment of eye infections. S02AA15 - ciprofloxacin; S03AA07 - ciprofloxacin; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations.