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L-CETRON

Contains
  • Indication

    Allergic conditions

  • Dosage

    Oral Allergic conditions Adult: As hydrochloride: 5 mg daily in the evening; 2.5 mg may be adequate in some patients. Max dose: 5 mg daily. Child: As hydrochloride: 6-11 yr: 2.5 mg once daily. Max dose: 2.5 mg daily. =12 yr: 5 mg once daily; 2.5 mg may be adequate is some patients. Max dose: 5 mg daily. All doses to be taken in the evening. CrCl (ml/min)Dosage Recommendation 50-802.5 mg once daily. 30-502.5 mg every other day. 10-302.5 mg twice wkly (give every 3-4 days).

  • Administration

    May be taken with or without food.

  • Overdosage

    Symptoms: Drowsiness, agitation, restlessness. Management: Supportive and symptomatic.

  • Contraindications

    Lactation. End-stage renal disease (CrCl <10 ml/min) or haemodialysis patients. Child 6-11 yr with renal impairment.

  • Special precautions

    Lactation. End-stage renal disease (CrCl <10 ml/min) or haemodialysis patients. Child 6-11 yr with renal impairment.

  • Adverse drug reactions

    Fatigue, somnolence, dry mouth, nasopharyngitis, pyrexia, cough, epistaxis.

  • Drug interaction

    Additive sedation with alcohol and other CNS depressants.

  • Pregnancy category

    Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1 st  trimester (and there is no evidence of a risk in later trimesters).

  • Storage

    Oral: Store at 20-25°C (68-77°F).

  • Mech of action

    Levocetirizine, an active isomer of cetirizine, selectively inhibits histamine H 1-receptors. Absorption: Rapidly and extensively absorbed from the GI tract (oral); peak plasma concentration in 0.9 hr. Distribution: Protein-binding: 91-92%. Metabolism: Via aromatic oxidation, N- and O-dealkylation and taurine conjugation. Excretion: Via urine (85.4%), via faeces (12.9%), as metabolites and unchanged drug; 8 hr (plasma half-life).

  • CIMS class

    Antihistamines & Antiallergics

  • ATC class

    R06AE09 - levocetirizine; Belongs to the class of piperazine derivatives used as systemic antihistamines.

  • Additional Info

    *levocetirizine information: levocetirizine further details are available in official CIMS India levocetirizine levocetirizine brands available in India Always prescribe with Generic Name : levocetirizine, formulation, and dose (along with brand name if r

 
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