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Indication
Food allergy,Mastocytosis,Allergic rhinitis,Asthma prophylaxis,Allergic conjunctivitis,
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Dosage
Oral Food allergy Adult: 200 mg four times daily. May double the dose if effect
is not satisfactory within 2-3 wk. Child: 100 mg four times daily. May double the dose if effect
is not satisfactory within 2-3 weeks. Max Dosage: 40 mg/kg/day. Renal impairment: Dosage adjustment may be needed. Hepatic impairment: Dosage adjustment may be needed. Oral Mastocytosis Adult: 200 mg four times daily. May double the dose if effect
is not satisfactory within 2-3 wk. Child: 100 mg four times daily. May double the dose if effect
is not satisfactory within 2-3 weeks. Max Dosage: 40 mg/kg/day. Renal impairment: Dosage adjustment may be needed. Hepatic impairment: Dosage adjustment may be needed. Nasal Allergic rhinitis Adult: 2.5 or 5 mg of a 2% or 4% soln is admin as drops or
spray into each nostril 4 times daily. Renal impairment: Dosage adjustment may be needed. Hepatic impairment: Dosage adjustment may be needed. Inhalation Asthma prophylaxis Adult: 20 mg four times daily as dry powder/nebulised soln or
10 mg four times daily as aerosol, increased to 6-8 times daily if necessary, reduced to 5 mg four times daily once asthma has been stabilised. Additional doses may be taken before exercise. Elderly: Renal impairment: Dosage adjustment may be needed. Hepatic impairment: Dosage adjustment may be needed. Ophthalmic Allergic conjunctivitis Adult: Instill 2 drops of a 4% soln 4-6 times daily or apply a
4% oint bid-tid. Elderly: Renal impairment: Dosage adjustment may be needed. Hepatic impairment: Dosage adjustment may be needed.
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Contraindications
Hypersensitivity.
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Special precautions
Hypersensitivity.
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Adverse drug reactions
Nausea, headache, dizziness, unpleasant taste, joint pain and swelling, skin rashes, aggravation of asthma, pulmonary infiltrates with eosinophilia, urticaria. Bronchospasm, wheezing, cough, nasal congestion and throat irritation following inhalation of dry powder. Intranasal use: Transient irritation of nasal mucosa. Sneezing and epistaxis (occasional). Eye drops: Transient burning and stinging.
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Mech of action
Cromoglycic acid inhibits degranulation of mast cells and therefore suppresses the release of histamine, leukotrienes and slow-reacting substance of anaphylaxis. Absorption: Oral: Poorly absorbed from the GIT with only 1%
bioavailability. Inhalation: 8-10% of a dose of fine powd is deposited and rapidly absorbed from the lungs. Intranasal: < 7% of the dose is absorbed. Ophthalmic: 0.03% is absorbed.
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Additional Info
sodium cromoglicate information: sodium cromoglicate sodium cromoglicate brands available in India Always prescribe with Generic Name : sodium cromoglicate, formulation, and dose (along with brand name if required)
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