ACICOT-OSYRUP

Contains

Indication

Peptic ulcer, Chronic gastritis, Prophylaxis of gastrointestinal haemorrhage from stress ulceration.

Dosage
- Oral Peptic ulcer Adult: 1 g 4 times daily or 2 g bid for 4-8 wk, may extend up to 12 wk if necessary.
- Maintenance dose of 1 g bid may be given to prevent the recurrence of duodenal ulcers. Max: 8 g daily.
- Child: 1 mth-2 yr: 250 mg 4-6 times daily; 2-12 yr: 500 mg 4-6 times daily and 12-18 yr: 1 g 4-6 times daily.
- Oral Chronic gastritis Adult: 1 g 4 times daily or 2 g bid for 4-8 wk, may extend up to 12 wk if necessary.
- Maintenance dose of 1 g bid may be given to prevent the recurrence of duodenal ulcers. Max: 8 g daily. Child: 1 mth-2 yr: 250 mg 4-6 times daily; 2-12 yr: 500 mg 4-6 times daily and 12-18 yr: 1 g 4-6 times daily.
- Oral Prophylaxis of gastrointestinal haemorrhage from stress ulceration Adult: 1 g 6 times daily. Not to exceed 8 g daily.
- Child: 1 mth-2 yr: 250 mg 4-6 times daily; 2-12 yr: 500 mg 4-6 times daily and 12-18 yr: 1 g 4-6 times daily.

Administration
Should be taken on an empty stomach. (Take on an empty stomach 1 hr before or 2 hr after meals.)

Overdosage
Sucralfate is poorly absorbed from the GI tract thus the risk from overdosage is minimal.

Adverse drug reactions
Constipation, diarrhoea, nausea, dizziness, dry mouth. GI disturbances, rash, pruritus, headache, vertigo, back pain, drowsiness.

Drug interaction
- Avoid antacids within 30 min of sucralfate admin.
- May reduce absorption of tetracyclines, ranitidine,ketoconazole, theophylline, phenytoin, cimetidine and digoxin (ensure a dosing interval of at least 2 hr between admin of sucralfate and other non-antacid medications).

Pregnancy category

Category B:
Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1 st trimester (and there is no evidence of a risk in later trimesters).

Mech of action
- Sucralfate protects GI lining against peptic acid, pepsin and bile salts by binding with positively-charged proteins in exudates forming a viscous paste-like adhesive substance thus forming a protective coating.
- Onset: 1-2 hr. Duration: 6 hr. Absorption: <5% after oral admin.
- Distribution: Acts locally at ulcer sites; unbound in GI tract to aluminum and sucrose sulfate.
- Excretion: Mainly in the urine.

ATC class
A02BX02 - sucralfate; Belongs to the class of other drugs used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

Additional Info
*sucralfate information: Note that there are some more drugs interacting with sucralfate sucralfate sucralfate brands available in India Always prescribe with Generic Name : sucralfate, formulation, and dose (along with brand name if required)