Henoch-Schonlein purpura is a disease inwhich there are purple spots on the skin, joint pain, gastrointestinal problemsand glomerulonephritis (a type of kidney disease). Purpura, arthritis andabdominal pain are the "classic triad" of Henoch-Schonlein purpura(HSP). Henoch-Schoenlein purpura (HSP) is a self-limiting disease.
The condition receives its name from thetwo physicians who first described this condition namely John Schonlein andEduard Henoch. It is a small vessel vasculitis having immunoglobulin A (IgA),C3 and immune complex deposits in the arterioles, capillaries and in thevenules.
CAUSES & RISK FACTORS
The exact cause is not known.
Antistreptolysin O titres are raised inabout 20 to 50% of the cases. Multiple factor like some foods, drugs, bites ofthe insects may as well trigger the Henoch Schonlein purpura (HSP).
SYMPTOMS & SIGNS
Rash mainly in the early stages may bepresent. It is more common on the legs.
Pain in the abdomen
Pain in the joints
Passing blood in the stools
Edema or swelling of the scrotum
Tenderness of the abdomen
About 14 cases are seen per 100000schoolchildren. The syndrome is usually seen in children but can affect peopleof all ages.
It is more common in boys than in girls.Male to female ration is about 2:1.
75% of the cases are from 2 to 11 years ofage. It can also occur in adults.
About 5% of the cases suffering fromHenoch- Schonlein purpura (HSP) have symptoms of the condition. Less than 1% ofHenoch Schonlein purpura (HSP) develops end stage renal failure.
There is no specific treatment. Most casesgo away on their own without treatment. The disease is self-limiting.
Analgesics can be used for abdominal painand joint pain. Anti-inflammatory medications are used such as Aspirin,Ibuprofen. Cortisone like prednisone orprednisolone is also used. Cyclophosphamide, azathioprine or mycophenolatemofetil is also used to suppress the immune system. Antibiotics are also used.Intravenous immunoglobulin (IVIG) is sometimes used.
Complication of medicaltreatment
Swelling of the face
Loss of appetite
The large movements
The skin rash
It is self limiting disease and can getbetter with time.