ANTI THYROGLOBULIN ANTIBODY

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Test Name
Anti-thyroglobulin antibody
Test Units
IU/mL
Normal Range
  • Positive
  • > 325
     
  • Negative
  • < 225
     
  • Equivocal
  • 225 - 325
    Sample required
    2 ml serum
     
    INTRODUCTION
     

    Antithyroglobulin antibody is a test to measure antibodies to a protein called thyroglobulin, which is found in thyroid cells. It helps in diagnosing autoimmune thyroid disease.

     
      ANTI THYROGLOBULIN ANTIBODY  
     
       
    CLINICAL SIGNIFICANCE
     
    It is found associated with :
     
    • Grave's disease
    • Hashimoto's thyroiditis
    • Hypothyroidism
    • Myxedema
    • Systemic lupus erythematosus (SLE)
    • Thyroid cancer
    • Thyrotoxicosis
    • Type 1 diabetes
    In conjunction with AMA, these antibody tests are used by many thyroidologists to confirm or rule out the involvement of autoimmune process in observed hyperthyroidism.
     
    T echnology Used ELISA
     
      ADDITIONAL INFORMATION  
     
     
    • Treatment for thyroid dysfunction may not reduce the titers of ATG and AMA.
    • Too high titers for too long periods suggest the possibility of permanent failure of thyroid.
    • If a hyperthyroid patient displays increased levels of ATG and or AMA, it is likely sooner or later the patient may become hypothyroid.
     
     
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