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Introduction
Zollinger-Ellison syndrome (ZES) is a condition in which there is increased production of the hormone gastrin by the tumor cells which leads to increased gastric acid resulting into severe peptic ulceration. The tumors which produce the hormone gastrin are called gastrinomas, which may occur as single tumors or as multiples.
The primary tumor is usually located in the duodenum (Upper part of small intestine), the pancreas, or the abdominal lymph nodes, but can also be sometimes found in abnormal locations such as heart, ovary, gall bladder, liver and kidney.
The mean age of onset of ZES is 43 years and there is slight male predominance.
Synonyms:
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