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Introduction
Parkinsonism is a disease characterized by bradykinesia (a paucity and slowness of movement), rest tremor, muscular rigidity, shuffling gait, and flexed posture, along with fixed facial expression (mask faces), infrequent blinking, reduce swallowing with consequent dribbling and slow monotonous speech.
Its peak age of onset is in the early 60s (range 35–85 years), and the course of the illness ranges between 10 to 25 years.
It is caused due to an abnormality in dopamine synthesis and release, particularly in basal ganglia of the brain. | |